C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) C07K 14/28 (2006.01) C07K 16/30 (2006.01) C12N 15/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2463492
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma.
Compositions et méthodes de diagnostic et de traitement de la croissance et de la prolifération de cellules néoplasiques chez les mammifères, en particulier chez l'homme. La présente invention repose sur l'identification de gènes qui sont amplifiés dans le génome de cellules tumorales, telles que celles du carcinome du rein. On estime que cette amplification génique est associée à la surexpression du produit génique, par comparaison à des cellules normales du même type de tissus, et qu'elle contribue à la genèse des tumeurs. Par conséquent, on estime que les protéines codées par les gènes amplifiés sont des cibles utiles pour le diagnostic et / ou le traitement (y compris la prévention) de certains cancers, tels que le carcinome du rein, et peut servir d'indicateur pour le pronostic du traitement des tumeurs. La présente invention concerne encore de nouvelles méthodes de diagnostic et de traitement des tumeurs, telles que le carcinome du rein.
Gerritsen Mary E.
Peale Franklin V. Jr.
Wu Thomas D.
Genentech Inc.
Smart & Biggar
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