Methods for the treatment of flavivirus infection, molecules...

Details Methods for the treatment of flavivirus infection, molecules... Methods for the treatment of flavivirus infection, molecules...

A - Human Necessities

61

K

A61K 39/00 (2006.01)

Patent

CA 2650591

The present invention relates to a method for blocking dengue virus infection of cells, which comprises interfering in the interaction of the virus envelope protein with a cell receptor directly or by means of a carrier protein, and to related uses, wherein the cell receptor is the alpha2 macroglobulin receptor, which is also known as the low-density lipoprotein receptor-related protein or CD91, and the carrier protein human alpha-2 macroglobulin.

L'invention concerne une méthode permettant de bloquer une infection par le virus de la dengue de cellules, ladite méthode consistant à interférer dans l'interaction de la protéine d'enveloppe du virus avec un récepteur cellulaire directement ou au moyen d'une protéine support, et des utilisations associées. Le récepteur cellulaire utilisé est le récepteur de l'alpha-2-macroglobuline qui est également connu en tant que protéine associée au récepteur de lipoprotéines de faible densité ou CD91, et la protéine support est la protéine alpha-2-macroglobuline humaine.

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