Methods for the treatment of graft-versus-host disease

Details Methods for the treatment of graft-versus-host disease Methods for the treatment of graft-versus-host disease

A - Human Necessities

61

K

A61K 38/16 (2006.01) A61K 35/28 (2006.01) A61K 39/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2739454

Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, or a polynucleotide encoding the flagellin, thereby treating or preventing graft versus host disease in the subject. Methods are also disclosed for reducing susceptibility to an opportunistic infection in a subject who is a bone marrow transplant recipient. The methods include selecting a subject who has had a bone marrow or hematopoietic stem cell transplant; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide or a polynucleotide encoding the polypeptide, and administering to the subject an effective amount antigen of the opportunistic infection, thereby reducing the susceptibility to the opportunistic infection in the subject.

La présente invention concerne des procédés pour traiter ou prévenir une réaction de greffe contre hôte chez un sujet. Les procédés comprennent la sélection dun sujet nécessitant un traitement pour une réaction de greffe contre hôte; et ladministration au sujet dune quantité thérapeutiquement efficace dun agoniste de TLR5 tel que le polypeptide flagelline, ou un polynucléotide codant pour la flagelline, de manière à traiter ou prévenir une réaction de greffe contre hôte chez le sujet. La présente invention concerne en outre des procédés pour réduire la susceptibilité dinfection opportuniste chez un sujet qui est un receveur de greffe de moelle osseuse. Les procédés comprennent la sélection dun sujet qui a subi une transplantation de moelle osseuse ou de cellules souches hématopoïétiques; et ladministration au sujet dune quantité thérapeutiquement efficace dun agoniste de TLR5 tel quun polypeptide de flagelline ou un polynucléotide codant pour le polypeptide, et ladministration au sujet dune quantité efficace dantigène de linfection opportuniste, de manière à réduire la susceptibilité dinfection opportuniste chez le sujet.

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