Methods for the treatment of inflammatory joint disease

Details Methods for the treatment of inflammatory joint disease Methods for the treatment of inflammatory joint disease

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2198706

The use of compounds that block complement component C5 or its active fragments C5a and/or C5b (such compounds collectively referred to as "C5 blockers") to treat established joint inflammation (arthritis) is disclosed. Administration of such C5 blockers has been found to: 1) arrest and/or reduce inflammation in joints which are already inflamed, and 2) inhibit the spread of inflammation to unaffected joints.

On décrit l'utilisation de composés qui bloquent le composant C5 du complément ou ses fragments actifs C5a et/ou C5b (ces composés étant qualifiés collectivement d'inhibiteurs de C5), pour traiter une arthrite établie. On a constaté que l'administration de ces inhibiteurs de C5 1) interrompent et/on réduisent l'inflammation des articulations déjà enflammées et 2) inhibent la propagation de l'inflammation à des articulations saines.

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