Methods for the treatment of non-thyroid disorders

A - Human Necessities – 61 – K

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A61K 38/30 (2006.01) A61K 31/198 (2006.01) A61K 31/4164 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 38/17 (2006.01) A61P 11/00 (2006.01) A61P 13/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2345642

Methods are disclosed for the treatment of non-thyroid disorders which respond to IGF, respond to IGFBP-3, or which are IGF-dependent. Thyroid axis agonists and IGF are administered to subjects suffering from non-thyroid disorders which respond to IGF, alleviating the symptoms of the disorders. Thyroid axis antagonists and IGFBP-3 are administered to subjects suffering from non- thyroid disorders which respond to IGFBP-3, alleviating the symptoms of the disorders. Thyroid axis antagonists are administered to subjects suffering from IGF-dependent non-thyroid disorders, thereby alleviating the symptoms of the disorders.

L'invention concerne des procédés permettant de traiter les troubles non thyroïdiens qui répondent à IGF, à IGFBP-3, ou qui sont indépendants de IGF. Les agonistes du tronc thyro-cervical et IGF sont administrés à des sujets souffrant de troubles non thyroïdiens répondant à IGF, afin d'atténuer les symptômes de ces troubles. Les antagonistes du tronc thyro-cervical et IGFBP-3 sont administrés à des sujets souffrant de troubles non thyroïdiens répondant à IGFBP-3, afin d'atténuer les symptômes de ces troubles. Enfin, les antagonistes du tronc thyro-cervical sont administrés aux sujets souffrant de troubles non thyroïdiens dépendants de IGF, afin d'atténuer les symptômes de ces troubles.

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