A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 31/167 (2006.01)
Patent
CA 2510042
Methods are disclosed for treating and preventing pain such as neuropathic pain, and traumatic injuries such as traumatic brain injury and acute spinal cord injury, which comprise administering effective amounts of a benzamide compound of formula I: (I) where n is 1 or 2, R1 is a group selected from acetyl, alkyl, amino, acylamino (NHCOR3), halo, nitro, and trifluoroalkyl, R2 is saturated alkyl of 3 to 5 atoms, and R3 is alkyl of 1 to 5 atoms. Pharmaceutical compositions, dosage forms and methods of administration are set forth.
L'invention concerne des méthodes de traitement et de prévention de la douleur, telle que la douleur neuropathique, et des traumatismes, tels que le traumatisme crânien et le traumatisme médullaire aigu, qui consistent à administrer des quantités effectives d'un composé benzamide de formule (I), dans laquelle n est 1 ou 2; R¿1? est un groupe choisi parmi acétyle, alkyle, amino, acylamino (NHCOR¿3?), halo, nitro et trifluoroalkyle; R¿2? est un alkyle saturé contenant 3 à 5 atomes; et R¿3? est un alkyle contenant 1 à 5 atomes. L'invention concerne en outre des compositions pharmaceutiques, des formes posologiques et des méthodes d'administration de l'invention.
Goodman Corey R.
Serafini Tito
Bereskin & Parr
Renovis Inc.
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