Methods for the treatment of substance abuse and dependence

Details Methods for the treatment of substance abuse and dependence Methods for the treatment of substance abuse and dependence

A - Human Necessities

61

K

A61K 31/137 (2006.01)

Patent

CA 2603519

The present invention relates to methods of and compositions for treating and relieving symptoms and disease associated with indications caused by a physiological drive to alleviate a sensation of anxiety. More specifically, the present invention relates to methods of and compositions for treating and relieving symptoms associated with substance abuse and withdrawal. The present invention relates to methods of and compositions for treating and relieving symptoms associated with addiction to antidepressants, opiates, nicotine or marijuana. In one method, a patient is treated with a composition that directly or indirectly modulates GABAA by modulating the expression of the GABAA receptor a4 subunit.

L'invention concerne des méthodes et des compositions permettant de traiter et de soulager des symptômes et des affections associés à des indications dues à une conduite physiologique visant à atténuer le sentiment d'anxiété. L'invention concerne plus spécifiquement des méthodes et des compositions permettant de traiter et de soulager des symptômes associés à la toxicomanie et au sevrage. L'invention concerne des méthodes et des compositions permettant de traiter et de soulager des symptômes associés à la dépendance aux antidépresseurs, aux opiacées, à la nicotine ou à la marijuana. Selon une méthode, un patient est traité avec une composition qui module directement ou indirectement GABAA par modulation de l'expression de la sous-unité du récepteur .alpha.4 de GABAA.

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