Methods for the treatment of tinnitus induced by cochlear...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/439 (2006.01) A61K 31/4535 (2006.01) A61K 31/517 (2006.01) A61K 31/662 (2006.01) A61K 49/00 (2006.01) A61P 27/16 (2006.01)

Patent

CA 2617661

The invention relates to methods for the prevention and/or treatment of tinnitus induced by cochlear excitotoxicity. In these methods, a pharmaceutical composition comprising an NMDA receptor antagonist is administered to an individual in need of such treatment by appropriate devices and/or formulations for local administration to the inner ear. The tinnitus to be prevented and/or treated may be provoked by acoustic trauma, presbycusis, ischemia, anoxia, treatment with one or more ototoxic medications, sudden deafness, or other cochlear excitotoxic-inducing occurrence. The invention also relates to method for the identification of compounds effective in the treatment and prevention of tinnitus by a novel screening method incorporating an electrophysiological test method.

L'invention porte sur des procédés destinés à la prévention et/ou au traitement des acouphènes provoqués par une excitotoxicité cochléaire. Dans ces procédés, une composition pharmaceutique comprenant un antagoniste des récepteurs NMDA est administrée à un individu ayant besoin d'un tel traitement, au moyen de dispositifs et/ou de formulations appropriés pour l'administration locale dans l'oreille interne. Les acouphènes à prévenir et/ou traiter peuvent être provoqués par un traumatisme acoustique, une presbyacousie, une ischémie, l'anoxie, un traitement par un ou plusieurs médicaments ototoxiques, une surdité soudaine ou tout autre phénomène provoquant une excitotoxicité cochléaire. L'invention porte également sur un procédé permettant l'identification de composés efficaces dans le traitement et la prévention des acouphènes par une nouvelle technique de criblage faisant intervenir une méthode d'essai électrophysiologique.

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