Methods for the treatment or prevention of conditions...

A - Human Necessities – 61 – K

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Details

A61K 31/55 (2006.01) A61K 31/135 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 209/12 (2006.01) C07D 307/80 (2006.01) C07D 333/56 (2006.01)

Patent

CA 2176127

This invention provides methods for the treatment or prevention of physiological disorders associated with an amy loidogenic peptide by the administration of a series of substituted naphthalenes, dihydronaphthalenes, benzofurans, benzothiophenes indoles, or the pharmaceutically acceptable salts or solvates thereof. This invention also provides methods for the treatment or prevention of Alzheimer's Disease or Down's Syndrome by the administration of these same benzofurans or benzothiophenes or the pharmaceutically acceptable salts thereof.

Procédés permettant de traiter ou de prévenir les dysfonctionemments physiologiques associés à un peptide amyloïdogène, selon lesquels on administre une série d'indoles de benzothiophènes, de benzofurannes, de dihydronaphtalènes, de naphtalènes substitués ou leurs sels ou solvates pharmaceutiquement acceptables. Sont également décrits des procédés permettant de traiter ou de prévenir la maladie d'Alzeimer ou le syndrome de Down, qui consistent à administrer ces mêmes benzofurannes ou benzothiophènes, ou leurs sels pharmaceutiquement acceptables.

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