Methods for the treatment or prevention of systemic sclerosis

Details Methods for the treatment or prevention of systemic sclerosis Methods for the treatment or prevention of systemic sclerosis

A - Human Necessities

61

K

A61K 38/00 (2006.01)

Patent

CA 2753824

The invention is in the field of molecular immunology, more in particular in the field of the prevention or treatment of autoimmune diseases, more in particular systemic sclerosis or scleroderma. The invention is based on the observation that SSC patients have an elevated plasma level of CXCL4. This was found to contribute to the pathogenesis of SSc, in particular fibrosis. When CXCL4 was neutralized in in vitro experiments, the fibrotic effects could be neutralized. This led us to conclude that SSc may be cured by reducing the plasma level of CXCL4. The invention therefore relates to a method for treatment or prevention of fibrosis in patients with scleroderma, wherein the plasma level of CXCL4 is reduced.

L'invention concerne le domaine de l'immunologie moléculaire, plus particulièrement le domaine de la prévention ou du traitement de maladies auto-immunes, plus spécifiquement la sclérose systémique ou la sclérodermie. L'invention est basée sur l'observation selon laquelle des patients SSc ont un taux élevé de CXCL4 dans le plasma. Ceci a été trouvé contribuer à la pathogenèse de la SSc (sclérodermie systémique), en particulier de la fibrose. Lorsque CXCL4 a été neutralisé dans des expériences in vitro, les effets fibrotiques ont pu être neutralisés. Ceci nous conduit à conclure que SSc peut être soigné par réduction du taux dans le plasma de CXCL4. L'invention porte par conséquent sur un procédé pour le traitement ou la prévention d'une fibrose chez des patients atteints de sclérodermie, le taux de CXCL4 dans le plasma étant réduit.

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