Methods for the use of inhibitors of co-repressors for the...

A - Human Necessities – 01 – N

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A01N 47/40 (2006.01) C07J 1/00 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 9/14 (2006.01) C12N 9/18 (2006.01) C12N 9/99 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2308377

The present invention is related to the use of histone deacetylase inhibitors as activators of genes responsive to hormone receptors and to counteract the oncogenic functions of oncogenic proteins. Histone deacetylase relieves repressed systems and, when in combination with a ligand for a member of the steroid/thyroid hormone superfamily, the differentiation effects of retinoids are enhanced. Formulations for modulating hormone-mediated processes and assays for the identification of potential modulators are presented.

Cette invention a trait à l'utilisation d'inhibiteurs d'histone désacétylase en tant qu'activateurs de gènes, qui, réagissant à des récepteurs hormonaux, se révèlent efficaces pour entraver les fonctions oncogènes de protéines oncogènes. L'histone désacétylase atténue la répression dans des systèmes réprimés et, associée à un ligand spécifique d'un membre de la super-famille des hormones stéroïdienne/thyroïdienne, favorise le renforcement des effets de différentiation des rétinoïdes. L'invention concerne également des formulations destinées à moduler des processus déclenchés par des hormones ainsi que des épreuves visant à l'identification de modulateurs potentiels.

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