C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/13 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2094341
Abstract Disclosed is a method that relates to the measurement of determinants related to the in-vivo induction of spermidine/ spermine Nl-acetyltransferase (SSAT), subsequent to treatment with polyamine analogs that induce SSAT such as bis-ethyl spermine analogs, in tumor types responsive to this class of analogs. The method comprises the measurement of one or more SSAT-specific determinants that include SSAT enzyme activity, SSAT enzyme protein, and SSAT m-RNA transcripts. Alternatively, other determinants related to the SSAT induction may be measured. Such determinants include SSAT co-factor acetylCoenzyme A, and SSAT products Nl-acetylspermidineand Nl-acetylspermine. Measurements of these determinants may be useful as prognostic indicia and tumor response markers to evaluate the clinical effectiveness of anticancer agents comprising polyamine analogs, such as bis-ethyl spermine analogs, that induce SSAT activity.
Health Research Inc.
Macrae & Co.
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