Methods for transducing cells in blood vessels using...

Details Methods for transducing cells in blood vessels using... Methods for transducing cells in blood vessels using...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2247099

Current techniques for expressing recombinant genes in cells of blood vessels following direct in vivo gene transfer are limited by attendant problems or limitations. Further, an effective method of transducing microvascular cells and/or cells involved in formation of new blood vessels (angiogenesis) has not been demonstrated. This invention provides methods of transducing cells in blood vessels using recombinant adeno-associated virus (AAV) vectors.

Les techniques actuelles visant à exprimer les gènes recombinants dans les cellules de vaisseaux sanguins après le transfert direct de gènes in vivo, se heurtent à des problèmes ou limitations connexes. En outre, aucun procédé efficace n'a été trouvé qui permette d'effectuer la transduction de cellules microvasculaires et/ou de cellules jouant un rôle dans la formation de nouveaux vaisseaux sanguins (angiogenèse). Cette invention concerne des procédés permettant d'effectuer la transduction de cellules dans des vaisseaux sanguins à l'aide de vecteurs de virus adéno-associés (VAA) recombinants.

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