Methods for transducing fusion molecules

C - Chemistry – Metallurgy – 12 – P

Patent

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C12P 21/04 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 1/113 (2006.01) C07K 14/025 (2006.01) C07K 14/16 (2006.01) C12N 1/20 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2330560

The present invention provides highly efficient methods of transducing a desired cell or group of cells including tissue or an organ with a fusion molecule, the method comprising, misfolding the fusion molecule; and contacting the misfolded fusion molecule to the cell under conditions sufficient to transduce the fusion molecule into the cell.

L'invention se rapporte à des méthodes particulièrement efficaces pour la transduction, à partir d'une molécule de fusion, d'une cellule souhaitée ou d'un groupe de cellules tel qu'un tissu ou un organe. Ladite méthode consiste à mal replier la particule de fusion et à mettre en contact ladite particule de fusion mal repliée avec la cellule en question dans des conditions permettant la transduction de la molécule de fusion en la cellule souhaitée.

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