A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/15 (2006.01) A61K 31/198 (2006.01) A61K 31/205 (2006.01) A61K 31/41 (2006.01) A61P 27/16 (2006.01)
Patent
CA 2658881
The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free radical scavengers, such as edaravone, resveratrol, ebselen and iron chelator and compounds from the family of antioxidant componds including, but not limited to, N-acetylcysteine (NAC), Acetyl-L-Carnitine (ALCAR), glutathione rnonoethylester, ebselen, D-methionine and carbamathione. The compositions of the current invention may be delivered by injections or orally.
La présente invention concerne des procédés et des compositions de traitement de la perte auditive sensorineuronale comprenant entre autres le traumatisme acoustique aigu. La composition comporte des composés qui fonctionnent comme des pièges de radicaux libres tels que le phényle butyle nitrone (PBN), des épurateurs de radicaux libres, tels que l'érédavone, le resvératrol, l'ebsélène, et le chélateur de fer et des composés dérivés de la famille de composés antioxydants comprenant, entre autres, le N-acétylcystéine (NAC), l'Acétyle-L-carnitine (ALCAR), le monoéthylester de glutathione, l'ebsélène, la D-méthionine et le carbaméthione. Les compositions de la présente invention peuvent être administrées par injection ou oralement.
Floyd Robert A.
Kopke Richard Dana
Hough Ear Institute
Oklahoma Medical Research Foundation
Ridout & Maybee Llp
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