Methods for treating alcoholism

A - Human Necessities – 61 – K

Patent

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A61K 31/496 (2006.01)

Patent

CA 2559743

In the treatment of alcoholism, co-treatment with an active agent capable of offsetting unwanted adverse clinical manifestations to the treatment itself, for example, negative drug adverse clinical manifestations, greatly increases patient compliance. Increasing patient compliance, in turn, creates a better success rate and decreased recidivism or relapse. The current invention combines the use of an opioid antagonist with at least one dopamine D2 partial agonist for the treatment of alcoholism. Suitable dopamine D2 partial agonists are aripiprazole and (-)3-(3-hydroxyphenyl)-N-n- propylpiperidine [(-)-3PPP].

La présente invention consiste à doubler le traitement anti-alcoolique par un traitement complémentaire au moyen d'un principe actif reportant sur le traitement anti-alcoolique lui-même les effets cliniques indésirables du médicament, ce qui permet une meilleure tolérance du traitement par le patient, et donc un meilleur taux de réussite, une moindre récidive ou rechute. En l'occurrence, l'invention associe à l'administration d'un antagoniste des opioïdes l'administration d'au moins un agoniste partiel de la dopamine D2 tel que l'aripiprazole et la (-)3-(3-hydroxyphényl)-N-n- propylpipéridine [(-)-3PPP].

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