Methods for treating and detecting beta-cell disease

Details Methods for treating and detecting beta-cell disease Methods for treating and detecting beta-cell disease

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2617807

The role of synaptic adhesion molecules in human cell development and function is largely unknown. This invention provides methods to study ß-cell function in native tissue through the use of novel adhesion and migrations assays. Through the use of these assays, the inventors have been able to for the first time describe the contribution of SAMs to human ß-cell adhesion, spreading, and motility. Furthermore, the inventors have used the results of these assays to develop methods for detection, treatment, and prevention of diseases related to the pancreas.

Le rôle des molécules d'adhésion synaptique dans le développement et la fonction d'une cellule humaine est largement connu. L'invention concerne des méthodes permettant d'étudier la fonction d'une cellule ß dans un tissu natif à travers l'utilisation de nouveaux essais d'adhésion et de migration. Via l'utilisation de ces essais, les inventeurs ont été capables, pour la première fois, de décrire la contribution des SAM à l'adhésion, la dispersion et la motilité des cellules ß humaines. Les inventeurs ont, en outre, utilisé les résultats de ces essais pour développer des méthodes de détection, de traitement et de prévention des maladies relatives au pancréas.

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