Methods for treating at least one condition having mt1...

A - Human Necessities – 61 – P

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A61P 25/06 (2006.01) A61K 31/277 (2006.01)

Patent

CA 2659037

The present invention is directed to methods comprising administering a composition comprising a therapeutically effective amount of (R)-verapamil, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein the composition treats, prevents and/or manages at least one condition having MT1 receptor, 5-HT2B receptor and L-type calcium channel activity and releases the (R)-verapamil, a derivative thereof or a pharmaceutically acceptable salt thereof to exhibit a co-primary activity on the MT1 receptor, the 5-HT2B receptor, and the L- type calcium channel.

La présente invention concerne des procédés comprenant l'administration d'une composition comprenant une quantité efficace d'un point de vue thérapeutique de (R)-vérapamil, un dérivé de celui-ci ou un sel acceptable du point de vue pharmaceutique de celui-ci, la composition traitant, prévenant et/ou gérant au moins une maladie ayant une activité de récepteur MT1, de récepteur 5-HT2B et de canal calcique de type L et libérant le (R)-vérapamil, un dérivé de celui-ci ou un sel acceptable du point de vue pharmaceutique de celui-ci pour présenter une activité co-primaire sur le récepteur MT1, le récepteur 5-HT2B et le canal calcique de type L.

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