A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A01K 67/027 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2417984
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of treating conditions resistant to treatment with TNFa inhibitors by administering agents that inhibit signal transduction by CD30 or IL-1. Included also are treatments involving concurrently administering agents that block the CD30/CD30L interaction and agents that antagonize the IL-4/IL-4R interaction. Additionally provided is an animal model for screening candidate agents for their efficacy in treating conditions that are resistant to treatment with TNFa inhibitors.
La présente invention concerne des méthodes de traitement de troubles inflammatoires chroniques et auto-immuns consistant à administrer des agents qui entravent l'interaction CD30/CD30L, des polythérapies, et des méthodes de traitement de troubles résistant au traitement aux inhibiteurs TNF.alpha., lesdites méthodes consistant à administrer des agents qui inhibent la transduction de signaux par CD30 ou IL-1. Cette invention concerne également des traitements qui mettent en jeu l'administration parallèle d'agents qui bloquent l'interaction CD30/CD30L et des agents qui agissent comme des antagonistes dans l'interaction IL-4/IL-4R. En outre, ladite invention concerne un modèle d'animal destiné au criblage d'agents candidats utilisés en raison de leur efficacité dans le traitement des troubles qui résistent au traitement aux inhibiteurs TNF.alpha..
Barone Dauphine S.
Kennedy Mary K.
Mohler Kendall M.
Peschon Jacques J.
Pluenneke John D.
Immunex Corporation
Smart & Biggar
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