Methods for treating cancer

Details Methods for treating cancer Methods for treating cancer

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/52 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2446589

Dendritic cells play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer and autoimmune disease, by facilitating the migration or activation of antigen-presenting dendritic cells. In particular, methods are provided for treating cancer in a mammal comprising administering to said mammal an effective amount of a targeting construct comprising 6Ckine or a biologically active fragment or variant thereof and a targeting moiety.

Les cellules dendritiques jouent un rôle critique dans les réponses immunitaires spécifiques d'un antigène. La présente invention se rapporte à des matières et à des méthodes permettant le traitement d'états pathologiques, et notamment du cancer et des maladies auto-immunes, et consistant à favoriser la migration ou l'activation de cellules dendritiques présentant un antigène. L'invention se rapporte particulièrement à des méthodes de traitement du cancer chez un mammifère qui consistent à administrer à ce mammifère une quantité efficace d'une construction de ciblage comportant une 6Ckine ou un fragment ou variant biologiquement actif d'une 6Ckine ainsi qu'un groupe caractéristique de ciblage.

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