Methods for treating cancer using a combination of a...

Details Methods for treating cancer using a combination of a... Methods for treating cancer using a combination of a...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/405 (2006.01) A61K 31/7088 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2468320

Dendritic cells (DC) play a critical role in antigen-specific immune responses. Materials and methods are provided for treating disease states, including cancer, by activating dendritic cells from the host which are rendered hypo-responsive to activation stimuli by the disease. In particular, methods are provided for treating cancer in a mammal comprising administering to said mammal an effective amount of a tumor-derived DC inhibitory factor antagonist in combination with an effective amount of a Toll-like receptor (TLR) agonist.

Les cellules dendritiques jouent un rôle critique dans les réponses immunes spécifiques d'antigène. L'invention concerne donc des matériaux et méthodes destinés au traitement de divers états maladifs, y compris du cancer, par activation de cellules dendritiques de l'hôte qui sont dans un état de sous-sensibilisation par rapport à la stimulation de l'activation provoquée par la maladie. L'invention concerne, en particulier des méthodes de traitement du cancer chez un mammifère qui consistent à administrer à ce mammifère une quantité efficace d'un antagoniste de facteur inhibiteur de cellule dendritique provenant d'une tumeur en combinaison avec une quantité efficace d'agoniste de récepteur de type Toll.

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