Methods for treating cancer using agents that inhibit wnt16...

A - Human Necessities – 61 – K

Patent

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A61K 48/00 (2006.01)

Patent

CA 2571955

This invention relates to methods of inhibiting the growth of cells, in particular cancer cells that over express Wnt16 protein. The methods comprise contacting the cell with an agent that binds to Wnt16 mRNA or Wnt16 protein, interferes with Wnt16 signaling or inhibits binding of the Wnt16 protein to another protein, such as a Frizzled receptor.

L'invention concerne des méthodes destinées à inhiber la croissance de cellules, et notamment de cellules cancéreuses surexprimant la protéine Wnt16. Ces méthodes consistent à mettre la cellule en contact avec un agent qui se lie à l'ARN messager de Wnt16 ou à la protéine Wnt16, qui interfère avec la signalisation de Wnt16 ou qui inhibe la liaison de la protéine Wnt16 à une autre protéine, telle que le récepteur Frizzled.

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