A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2597638
The present invention provides a modified toxin having an ETA moiety that has the furin site replaced with a cancer-associated protease site. The present invention also provides modified immunotoxins having a ligand that binds to a cancer cell attached to an ETA moiety that has the furin site replaced with a cancer-associated protease site. Also provided are a method of inhibiting or destroying mammalian cancer cells using the immunotoxins of the invention and pharmaceutical compositions for treating human cancer.
La présente invention concerne une toxine modifiée comprenant un fragment ETA dont le site furine est remplacé par un site protéase associé au cancer. Cette invention concerne également des immunotoxines modifiées qui comprennent un ligand qui se lie à une cellule cancéreuse fixée à un fragment ETA dont le site furine est remplacé par un site protéase associé au cancer. Cette invention concerne en outre un procédé permettant d'inhiber ou de détruire des cellules cancéreuses mammifères à l'aide des immunotoxines de cette invention, ainsi que des compositions pharmaceutiques utilisées pour traiter un cancer humain.
Di Paolo Claudio
Zangemeister-Wittke Uwe
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Zuerich
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