Methods for treating cancer using anti-wnt2 monoclonal...

Details Methods for treating cancer using anti-wnt2 monoclonal... Methods for treating cancer using anti-wnt2 monoclonal...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2566498

This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor.

L'invention concerne des procédés d'inhibition de la croissance de certaines cellules, en particulier les cellules cancéreuses, qui surexpriment Wnt2. Les procédés consistent à mettre en contact la cellule avec un agent qui se lie à l'ARNm Wnt2 ou à la protéine Wnt2, qui interfère avec la signalisation Wnt2 ou qui inhibe la liaison de la protéine Wnt2 avec une autre protéine, telle que le récepteur Frizzled.

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