Methods for treating cancers and restenosis with p21

Details Methods for treating cancers and restenosis with p21 Methods for treating cancers and restenosis with p21

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2232985

The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.

Le gène p21 code un inhibiteur de la kinase dépendante de la cycline qui affecte la progression du cycle cellulaire, mais le rôle de ce gène dans la modification de la croissance des tumeurs n'a pas été établi. Les inventeurs de la présente invention ont à présent découvert que la croissance de cellules malignes in vivo est altérée par l'expression de p21. L'expression de p21 a entraîné une accumulation de cellules dans G0/G1, une altération de morphologie et une différenciation cellulaire.

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