Methods for treating cell proliferative disorders and viral...

Details Methods for treating cell proliferative disorders and viral... Methods for treating cell proliferative disorders and viral...

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 31/336 (2006.01) A61K 31/365 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2417495

The present invention concerns methods for treating cell proliferative diseases, tumors associated with viral infections, and certain viral infections. The disclosed methods use compounds which inhibit heat shock protein 90 proteins. Such methods block Rb negative or deficient cells in the G2/M phase of the cell cycle and rapidly causes their destruction.

L'invention concerne des méthodes de traitement de maladies de prolifération cellulaire, de tumeurs associées à des infections virales, et de certaines infections virales. Dans les méthodes décrites, on utilise des composés qui inhibent des protéines 90 de choc thermique. De telles méthodes permettent de bloquer des cellules négatives ou déficientes en Rb dans la phase G¿2?/M du cycle cellulaire et de provoquer rapidement leur destruction.

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