Methods for treating certain diseases using naaladase...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/194 (2006.01) A61K 31/662 (2006.01) A61P 3/10 (2006.01) A61P 11/00 (2006.01) A61P 15/08 (2006.01) A61P 17/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2354052

A method for regulating the release of TGF-.beta. from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting neuroregeneration, cell proliferation, cell differentiation, extracellular matrix formation, myelination, inflammation, immune function, liver function, pancreatic function, angiogenesis, or wound healing; and/or preventing or treating diabetes.

L'invention concerne un procédé permettant de réguler la libération de TGF-.beta. de cellules vivantes in vitro ou in vivo, qui comporte l'étape consistant à mettre les cellules en contact avec une quantité efficace d'un inhibiteur de NAALADase. Les procédés de l'invention permettent d'agir sur la neurorégénération, la prolifération cellulaire, la différenciation cellulaire, la formation de matrice extracellulaire, myélinisation, l'inflammation, la fonction immunitaire, la fonction hépatique, la fonction pancréatique, l'angiogenèse ou la cicatrisation des plaies; et/ou de prévenir ou traiter le diabète.

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