Methods for treating chemotherapy and radiation therapy side...

A - Human Necessities – 61 – K

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A61K 31/382 (2006.01) A61K 31/192 (2006.01) A61K 31/194 (2006.01) A61K 31/196 (2006.01) A61K 31/235 (2006.01) A61K 31/352 (2006.01) A61P 7/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2651487

A method for treating chemo therapy or radiation therapy side effects in a mammal undergoing chemotherapy and/or radiation therapy, the method comprising a step of administering to the mammal a therapeutically effective amount of a RAR antagonist or RAR inverse agonist which binds to receptors of the RAR.alpha., RAR.beta. and RAR.gamma. subtypes is disclosed. Such side effects include chemoradiotherapy-induced alopecia, chemoradiotherapy-induced thrombocytopenia, chemoradiotherapy-induced leucopenia and chemoradiotherapy-induced neutropenia.

L'invention concerne une méthode destinée à traiter les effets secondaires de la chimiothérapie ou de la radiothérapie. Cette méthode consiste à administrer à un mammifère une dose thérapeutiquement efficace d'un antagoniste de RAR ou d'un agoniste inverse de RAR se liant aux récepteurs des sous-types RARa, RARß et RAR?. Ces effets secondaires incluent l'alopécie induite par la chimioradiothérapie, la thrombocytopénie induite par la chimioradiothérapie, la leucopénie induite par la chimioradiothérapie et la neutropénie induite par la chimioradiothérapie.

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