C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/50 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01)
Patent
CA 2581980
The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGF.beta., or using agents that inhibit TGF.beta., or using agents that inhibit TGF.beta. in combination with agents that degrade excess accumulated extracellular matrix, or at least one agent that degrades excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a subject.
La présente invention concerne des méthodes et des compositions de réduction et de prévention d'une accumulation excessive de matrice extracellulaire dans un tissu et/ou un organe sur le site d'une plaie à l'aide d'une combinaison d'agents inhibant le TGFß, ou à l'aide d'agents inhibant le TGFß, ou à l'aide d'agents inhibant le TGFß en combinaison avec des agents de dégradation de l'accumulation excessive de matrice extracellulaire, ou au moins un agent de dégradation de l'accumulation excessive de matrice extracellulaire. Les compositions et les méthodes de l'invention sont utilisées pour traiter les états tels que les maladies fibrotiques et les cicatrices résultant d'une accumulation excessive de matrice extracellulaire, affaiblissant la fonction d'un tissu ou d'un organe, ou l'apparence de la peau, chez un sujet.
Border Wayne A.
Noble Nancy A.
Cassan Maclean
University Of Utah Research Foundation
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