Methods for treating conditions associated with the...

A - Human Necessities – 61 – K

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Details

A61K 31/00 (2006.01) A61K 31/401 (2006.01) A61K 31/4178 (2006.01) A61K 38/14 (2006.01) A61K 38/55 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2358400

The present invention is methods and compositions for reducing and preventing the excess accumulation of extracellular matrix in a tissue and/or organ or at a wound site using a combination of agents that inhibit TGF.beta., or using agents that inhibit TGF.beta. in combination with agents that degrade excess accumulated extracellular matrix. The compositions and methods of the invention are used to treat conditions such as fibrotic diseases and scarring that result from excess accumulation of extracellular matrix, impairing tissue or organ function or skin appearance in a suject.

La présente invention concerne divers procédés et diverses compositions pour réduire et empêcher un excédent de matrice extracellulaire dans un tissu et/ou un organe ou à l'emplacement d'une plaie. On utilise une combinaison d'agents inhibiteurs du TGF-bêta ou des agents inhibiteurs du TGF-bêta combinés avec des agents qui réduisent l'excédent de matrice extracellulaire. Les combinaisons et les procédés présentés sont utilisés pour le traitement des états tels que les fibroses et la cicatrisation qui résultent d'un excédent de matrice extracellulaire, altérant le tissu ou le fonctionnement d'un organe, ou encore l'aspect extérieur de la peau d'un sujet.

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