A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/16 (2006.01) A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/535 (2006.01) A61K 31/5375 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01)
Patent
CA 2336549
The present invention includes methods for treatment and prophylaxis of conditions associated with lactosylceramide. The methods generally provide for administration to a mammal, particularly a human, of a therapeutically effective amount of a compound that increases enzymatic activity of UDPGal:GlcCer.beta.14 galactosylceramide (Ga1T-2). In vitro and in vivo assays for detecting compounds with therapeutic capacity to modulate Ga1T-2 are also provided.
L'invention concerne des méthodes de traitement et de prophylaxie d'états associés à la lactosylcéramide. Ces méthodes consistent généralement à administrer à un mammifère, notamment à l'homme, une dose efficace sur le plan thérapeutique d'un composé augmentant l'activité enzymatique de la UDPGal/GlcCer.beta.1?4 galactosylcéramide (GalT-2). L'invention concerne également des dosages in vitro et in vivo de détection de composés capables, sur le plan thérapeutique, de moduler GalT-2.
Johns Hopkins University
Sim & Mcburney
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