Methods for treating diabetes

A - Human Necessities – 61 – K

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A61K 35/12 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2650638

Transplantation of multipotent stromal cells (MSCs) into diabetic mice lowers blood sugar, increases blood insulin levels, increases the number and size of islets, and improves renal pathology. Accordingly, the invention provides methods for treating or preventing diabetes by administering isolated MSCs. The invention also provides methods for treating or preventing complications which arise from diabetes, including diabetic nephropathy, by transplanting isolated MSCs.

L'invention concerne une transplantation de cellules souches mésenchymateuses (CSM) chez des souris diabétiques pour abaisser la glycémie, augmenter les niveaux sanguins d'insuline, augmenter le nombre et la taille d'îlots et soulager une pathologie rénale. En conséquence, l'invention concerne des méthodes pour traiter ou prévenir le diabète en administrant des CSM isolées. L'invention concerne aussi des méthodes pour traiter ou prévenir les complications du diabète, y compris une néphropathie diabétique, par transplantation de CSM isolées.

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