A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/28 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01)
Patent
CA 2534432
The methods of the invention relate to the treatment of diabetes, including type 2 diabetes, and related disorders by administration of a PDE10A inhibitor. Such PDE10A inhibitors may be administered in conjunction with alpha-glucosidase inhibitors, insulin sensitizers, insulin secretagogues, hepatic glucose output lowering compounds, .szlig.-3 agonist, or insulin. Such PDE10A inhibitors may also be administered in conjunction with body weight reducing agents. Further methods of the invention relate to stimulating insulin release from pancreatic cells, for example, in response to an elevation in blood glucose concentration, by administration of a PDE10A inhibitor.
Les procédés de l'invention concernent le traitement du diabète, y compris le diabète non insulino-dépendant, et les troubles associés, par administration d'un inhibiteur des PDE10A. De tels inhibiteurs des PDE10A peuvent s'administrer conjointement avec des inhibiteurs de l'.alpha.-glucosidase, des sensibilisants insuliniques, des sécrétagogues, des composés abaissant la production de glucose hépatique, un agoniste du .beta.-3, ou l'insuline. De tels inhibiteurs des PDE10A peuvent également s'administrer conjointement avec des agents de perte de poids. D'autres procédés de l'invention se rapportent à la stimulation de la libération d'insuline par les cellules du pancréas, par exemple, en réaction à une augmentation de la glycémie, par administration d'un inhibiteur des PDE10A.
Bayer Pharmaceuticals Corporation
Borden Ladner Gervais Llp
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