Methods for treating diabetes by inhibiting gdf-8

Details Methods for treating diabetes by inhibiting gdf-8 Methods for treating diabetes by inhibiting gdf-8

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01)

Patent

CA 2331410

Methods for treating diabetes by administering an inhibitor of GDF-8, or a related member of Transforming Growth Factor-beta (TGF-.beta.) superfamily of structurally-related growth factors (e.g., GDF-11) are disclosed. Also disclosed are methods for upregulating expression of hexose transporters, such as GLUT4 and GLUT1, in a subject by administering an inhibitor of GDF-8. Also disclosed are methods for increasing glucose uptake by cells in a subject, by administering an inhibitor of GDF-8.

L'invention se rapporte à des méthodes de traitement du diabète consistant à administrer un inhibiteur de GDF-8, ou un élément associé de la superfamille du facteur de croissance transformant bêta (TGF- beta ) constituée des facteurs de croissance structurellement associés (par exemple, GDF-11). L'invention se rapporte également à des méthodes visant à effectuer, chez un sujet, une régulation positive de l'expression des transporteurs d'hexose, tels que GLUT4 et GLUT1, et consistant à administrer audit sujet un inhibiteur de GDF-8. L'invention se rapporte également à des méthodes visant à accroître l'assimilation de glucose par les cellules chez un sujet, et consistant à administrer un inhibiteur de GDF-8.

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