Methods for treating diseases involving stress-related...

Details Methods for treating diseases involving stress-related... Methods for treating diseases involving stress-related...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 41/00 (2006.01) A61M 1/38 (2006.01) C40B 30/00 (2006.01) C40B 40/06 (2006.01) A61K 31/01 (2006.01) A61K 31/4353 (2006.01)

Patent

CA 2651542

The present invention provides a unique mode of action for Extracorporeal Photopheresis (ECP). ECP may act through modulation of cellular stress responses characteristic of evolutionarily conserved mechanism for responding to environmental stress (i.e. responses to infection and varied nutrient availability, obesity, xenobiotics). A specific pathway, the hexosamine metabolic pathway appears to modulate this stress response by-altering cellular O-linked glycoprotein composition.

L'invention concerne un mode unique d'action de photophérèse extracorporelle (ECP). L'ECP peut agir par modulation des réponses au stress cellulaire caractérisant un mécanisme conservé au cours de l'évolution pour répondre au stress environnemental (à savoir des réponses à l'infection, à différents apports nutritifs, à l'obésité, à des substances xénobiotiques). Une voie spécifique, la voie métabolique de l'hexosamine, s'avère apte à moduler cette réponse au stress par altération de la composition cellulaire de la glycoprotéine à liaison O.

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