A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/21 (2006.01) A61K 31/405 (2006.01)
Patent
CA 2558766
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MPT inhibitor. In some embodiments the method comprises administering at least three stepwise, increasing dosages of the MPT inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.
La présente invention concerne des procédés et compositions destinées au traitement de l'hyperlipidémie et/ou de l'hypercholestérolémie par administration au sujet d'une quantité suffisante d'un inhibiteur des MTP (Microsomal Triglyceride Transfer Protein) pour bloquer l'hyperlipidémie et/ou l'hypercholestérolémie chez ce sujet, ladite administration impliquant des séries croissantes de doses posologiques de l'inhibiteur des MTP. Dans certains modes de réalisation, le traitement nécessite l'administration au sujet de doses de l'inhibiteur des MTP augmentant en trois paliers successifs. Dans certains modes de réalisation, le procédé implique également d'administration d'au moins un composé modifiant d'autres lipides.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Trustees Of The University Of Pennsylvania
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