Methods for treating genetically-defined proliferative...

Details Methods for treating genetically-defined proliferative... Methods for treating genetically-defined proliferative...

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 31/365 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) C07G 11/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2440809

The invention relates generally to methods of treating cell proliferative diseases with HSP90 inhibitors and, depending on the specific aspect and embodiment(s) claimed, to the treatment of proliferative diseases that are associated with fusion proteins, e.g., bcrabl, or mutant proteins or cellular protein isoforms, e.g., mutant forms of p53.

L'invention concerne généralement des procédés de traitement de maladies à prolifération cellulaire par des inhibiteurs de HSP90 et, en fonction de l'aspect spécifiques et des revendications, concerne le traitement de maladies prolifératives associées à des protéines de fusion, notamment bcrabl, ou à des protéines mutantes ou à des isoformes de protéines cellulaires, notamment des formes mutantes de p53.

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