C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01)
Patent
CA 2670563
Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
L'invention concerne des composés anti-sens et des procédés destinés à diminuer le LDL-C chez un individu ayant un LDL-C élevé. Sont également révélés des composés anti-sens et des procédés pour traiter l'hypercholestérolémie, ou en variante, pour traiter ou prévenir l'athérosclérose. Sont en outre révélés des composés anti-sens et des procédés pour diminuer le risque de maladies coronariennes. De tels procédés comprennent une administration à un individu en besoin de traitement d'un composé anti-sens ciblant l'acide nucléique PCSK9. Les composés anti-sens administrés comprennent des oligonucléotides anti-sens gapmer.
Bhanot Sanjay
Crooke Rosanne M.
Freier Susan M.
Graham Mark J.
Lemonidis Tarbet Kristina
Isis Pharmaceuticals Inc.
Smart & Biggar
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