A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2621539
Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation, Immune complexed IgG to IgG F.gamma.R binding, and immune complexed IgG mC1q (membrane C1q) or soluble C1q binding. Such compounds may have therapeutic use in treating amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), and Alzheimer's disease (AD).
La présente invention se rapporte à des polypeptides et à d'autres composés qui se lient spécifiquement à la fissure CH2-CH3 d'une molécule d'immunoglobuline, et à des procédés destinés à utiliser lesdits polypeptides et composés pour inhiber la formation de complexes immuns provoquée par Fc, la liaison de IgG à IgG F?R sous forme de complexe immun, et la liaison de IgG à mC1q (C1q membranaire) ou à C1q soluble sous forme de complexe immun. De tels composés peuvent avoir une utilisation thérapeutique visant à traiter la sclérose latérale amyotrophique (ALS), la maladie de Parkinson (PD) et la maladie d'Alzheimer (AD).
Altman Elliot
Bodie Neil M.
Bodie Renee
Mbm Intellectual Property Law Llp
Trinity Therapeutics Inc.
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