Methods for treating implantable biological tissues to...

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61L 27/36 (2006.01)

Patent

CA 2196165

A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Alternatively, methods other than heating (e. g., chemical or mechanical means) , for effecting polymerization of the glutaraldehyde may also be utilized. Alternatively, the tissue may be heat treated prior to fixing thereof. Alternatively, methods other than glutaraldehyde may also be used far fixing the tissue. The biological tissue may be so treated at any time prior to implantation thereof in a mammalian body.

Un procédé de traitement des tissus biologiques fixes inhibe la calcification de ces derniers après leur implantation dans le corps d'un mammifère. Le procédé consiste à mettre les tissus biologiques en contact avec du glutaraldéhyde puis à chauffer ce dernier. On peut également employer d'autres procédés que le chauffage (un procédé chimique ou mécanique par exemple) pour polymériser le glutaraldéhyde, de même qu'on peut traiter thermiquement les tissus avant de les fixer, et qu'on peut utiliser des procédés sans glutaraldéhyde pour fixer les tissus. Les tissus biologiques peuvent être traités de la sorte à un moment quelconque avant leur implantation dans un corps de mammifère.

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