Methods for treating inflammation

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/575 (2006.01) A61K 38/17 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) C07K 14/47 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2722668

Provided are methods and compositions for reducing airway hyperresponsiveness and other inflammatory diseases, disorders and conditions in a mammal by decreasing FIZZ 1(Found in Inflammatory Zone 1) activity. Also provided are methods and compositions for identifying modulators of airway inflammation and/or inhibitors of FIZZ 1. The present invention encompasses modulators of airway inflammation and/or inhibitors of FIZZ 1 and uses thereof. In addition, the present invention provides methods and compositions for enhancing an immune response based on FIZZ 1 protein.

La présente invention concerne des méthodes et des compositions permettant de réduire lhypersensibilité des voies aériennes et autres maladies, troubles et affections inflammatoires chez un mammifère par diminution de lactivité de FIZZ 1(Found in Inflammatory Zone 1). Linvention concerne également des méthodes et des compositions permettant didentifier les modulateurs de linflammation des voies aériennes et/ou les inhibiteurs de FIZZ 1. La présente invention couvre les modulateurs de linflammation des voies aériennes et/ou les inhibiteurs de FIZZ 1 ainsi que leurs utilisations. De plus, la présente invention concerne des méthodes et des compositions permettant daugmenter la réponse immunitaire basée sur la protéine FIZZ 1.

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