C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 271/22 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 31/27 (2006.01) A61K 38/05 (2006.01) C07C 233/51 (2006.01) C07C 235/34 (2006.01) C07C 271/16 (2006.01) C07C 323/58 (2006.01) C07K 5/06 (2006.01)
Patent
CA 2083134
ABSTRACT OF THE DISCLOSURE The present invention relates to a method of treating an inflammatory condition, and to compounds and composition suitable for use in such a method, which compounds have the Formula: Image wherein: X is methylene, ethylene, ethyleneoxy, or oxygen; Q is Image where C' is a residue of a lipophilic amino acid, and Y is -CO2H, -CH2OH, -CONR1R2, or CO2R1 where R1 and R3 are hydrogen, alkyl, or aryl; R3 and R4 are, independently, hydrogen, alkyl or aryl; and A and B are, independently, hydrogen, fused phenyl, alkyl, aryl, alkaryl, aralkyl, alkoxy, alkoxyalkyl, halogen, or nitro; or pharmaceutically acceptable salts thereof. with the proviso that when A, B, R" and R4 are hydrogen and Y is -CO2H (or salt thereof), X is not oxygen, and with the further proviso that when A or B are, independently, hydrogen or halogen, R3 and R4 are hydrogen, X is oxygen, and Y is -CO2H (or salt thereof), C' is not an aromatic amino acid residue.
Burch Ronald M.
Weitzberg Moshe
Burch Ronald M.
Moffat & Co.
Weitzberg Moshe
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