A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/455 (2006.01) A61K 39/05 (2006.01) A61K 39/104 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2442003
Method for preventing neural tissue damage caused by ADP-ribosylation of eucaryotic elongation factor-2 (EF-2) are disclosed. These methods are especially iseful in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and other cognitive disorders of mammals. Also described are methods to screen for drugs that wouls be useful for treating such diseases.
La présente invention concerne une méthode visant à empêcher des dommages du tissu nerveux causés par l'ADP-ribosylation du facteur 2 (EF-2) d'élongation eucaryotique. Ces méthodes sont particulièrement utiles dans le traitement de maladies neurodégénératives, telles que la maladie d'Alzheimer, la maladie de Parkinson, et autres troubles cognitifs de mammifères. L'invention concerne également des méthodes de criblage de médicaments qui peuvent être utiles pour traiter de telles maladies.
Ghanbari Hossein A.
Merril Carl R.
Ghanbari Hossein A.
Merril Carl R.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Panacea Pharmaceuticals Inc.
The Government Of The United States Of America
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