A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/573 (2006.01) A61K 31/57 (2006.01) A61P 27/00 (2006.01) A61P 27/02 (2006.01)
Patent
CA 2753847
A method of treating blepharitis includes administering to the affected eye of a subject an effective amount of an active ingredient in an ophthalmically acceptable vehicle for a sufficient period of time to treat blepharitis. The active ingredient consists essentially of a glucocorticoid in an ophthalmically acceptable vehicle that includes an aqueous polymer suspension that when mixed with tear fluid provides a sustained release of said active ingredient. The aqueous polymer suspension includes a carboxyl-containing polymer having less than about 5% by weight cross-linking agent and has a viscosity in a range from about 1,000 to about 30,000 centipoises. A kit includes: (a) a composition comprising about 0.1% by weight dexamethasone in this ophthalmically acceptable vehicle and (b) instructions for using the composition of (a) for the treatment of blepharitis.
La présente invention concerne une méthode permettant de traiter la blépharite et consistant à administrer à l'oeil affecté d'un patient une quantité efficace d'un principe actif dans un excipient ophtalmiquement acceptable pendant un laps de temps suffisant pour traiter la blépharite. Le principe actif consiste essentiellement en un glucocorticoïde dans un excipient ophtalmiquement acceptable qui contient une suspension polymère aqueuse, qui lorsqu'il se mélange au liquide lacrimal permet d'obtenir une libération lente dudit principe actif. La suspension polymère aqueuse comprend un polymère contenant du carboxyle présentant moins de 5% en poids d'un agent de réticulation et une viscosité comprise entre environ 1000 et environ 30000 centipoises. Une trousse contient: (a) une composition comprenant environ 0,1% en poids de dexaméthasone dans l'excipient ophtalmiquement acceptable et (b) des instructions pour utiliser la composition (a) pour traiter la blépharite.
Bowman Lyle M.
Hosseini Kamran
Insite Vision Incorporated
Robic
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