A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61P 35/00 (2006.01) A61K 9/70 (2006.01)
Patent
CA 2359109
Biodegradable polymer compositions suitable for intraperitoneal administration to treat a mammalian subject having ovarian cancer are described. The composition comprising: (a) at least one antineoplastic agent and (b) a biodegradable phosphoester polymer wherein the polymer composition provides extended release of the antineoplastic agent into the peritoneum of the subject; wherein the polymer composition increases the median survival rate from the cancer by at least about 10%, as compared with the median survival rate obtained by administration of a composition comprising the same dosage of the antineoplastic agent without the biodegradable polymer. Solid articles and methods for treating ovarian cancer are also described.
L'invention concerne un composition polymère biodégradable pour administration intrapéritonéale pour traitement d'un sujet mammifère atteint d'un cancer des ovaires. Ladite composition renferme (a) au moins un agent antinéoplastique et (b) un polymère phosphoester biodégradable. La composition polymère permet une libération étendue de l'agent anitnéoplastique à l'intérieur du péritoine du sujet. Elle augmente le taux de survie médian d'au moins 10 % par rapport à celui obtenu par administration d'une composition renfermant le même dosage dudit agent ne contenant pas de polymère biodégradable. L'invention porte également sur des articles solides et des procédés permettant de traiter le cancer des ovaires.
Eisai Inc.
Guilford Pharmaceuticals Inc.
Ridout & Maybee Llp
LandOfFree
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