Methods for treating photoreceptors using glial cell...

A - Human Necessities – 61 – K

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A61K 38/18 (2006.01) A61K 35/12 (2006.01) A61K 35/44 (2006.01) A61K 38/30 (2006.01)

Patent

CA 2236157

The present invention relates generally to methods for treating injury or degeneration of retinal neurons, and in particular photoreceptors, by administering glial cell line-derived neurotrophic factor (GDNF). The invention relates specifically to methods for treating retinal conditions or diseases in which vision is lost such as retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, peripheral vitreoretinopathies, photic retinopathies, surgery-induced retinopathies, viral retinopathies, ischemic retinopathies, retinal detachment and traumatic retinopathy.

La présente invention concerne, de manière générale, des procédés de traitement de blessures ou de dégénérescence des neurones rétiniens et, plus particulièrement, des photorécepteurs, lesquels procédés consistent à administrer un facteur neurotrophique dérivé de lignée cellulaire gliale (GDNF). Cette invention concerne plus particulièrement des procédés de traitement de conditions ou de maladies rétiniennes entraînant une perte de la vue, tel que la rétinite pigmentaire, la dégénérescence maculaire due au vieillissement, la rétinopathie diabétique, les vitréo-rétinopathies périphériques, les rétinopathies photiques, les rétinopathies causées par des interventions chirurgicales, les rétinopathies virales, les rétinopathies ischémiques, le décollement de la rétine et la rétinopathie traumatique.

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