Methods for treating proliferative diseases and for...

Details Methods for treating proliferative diseases and for... Methods for treating proliferative diseases and for...

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2522333

The present invention relates to phosphoproteins useful as biomarkers for identifying and treating patients suffering from diseases characterized by an aberrant MAP kinase signaling pathway, for example proliferative diseases like certain cancers, monitoring the efficacy of treatment of patients having the disease by administering Raf kinase inhibitors and diagnosing the disease in patients.

La présente invention concerne des phosphoprotéines utilisées comme biomarqueurs d'une part pour identifier et traiter des patients souffrant de maladies qui se caractérisent par une voie de signalisation MAP kinase aberrante, par exemple des maladies prolifératives telles que certains cancers, et d'autre part pour surveiller l'efficacité du traitement de patients atteints de cette maladie, le traitement consistant à administrer des inhibiteurs de la kinase Raf, et pour diagnostiquer la maladie chez des patients.

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