Methods for treating psychosis associated with...

A - Human Necessities – 61 – K

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A61K 31/567 (2006.01) A61K 9/20 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2302586

This invention generally pertains to the field of psychiatry. In particular, this invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for ameliorationg pathologies or conditions associated with psychosis. These pathologies or conditions include psychotic major depression, schizoaffective disorders, Alzheimer's Disease and cocaine addiction. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods. The invention also provides a kit for the amelioration of psychosis in a human including a glucocorticoid receptor antagonist and instructional material teaching the indications, dosage and schedule of administration of the glucocorticoid receptor antagonist.

La présente invention concerne généralement le domaine de la psychiatrie. Cette invention concerne notamment la découverte que des agents inhibant la liaison d'hydrocortisone à ses récepteurs peuvent être utilisés dans des méthodes de traitement de pathologies ou de troubles associés à la psychose. Ces pathologies ou troubles comprennent la dépression grave psychotique, les troubles schizo-affectifs, la maladie d'Alzheimer et la cocaïnomanie. La Mifépristone, un antagoniste puissant du récepteur de glucocorticoïdes, peut être utilisée dans ces méthodes. L'invention concerne également une trousse de traitement de la psychose chez un humain, la trousse comprenant un antagoniste du récepteur de glucocorticoïdes et un équipement d'instruction fournissant les indications, la posologie et le mode d'administration de l'antagoniste du récepteur de glucocorticoïdes.

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