Methods for treating resistant tumors

Details Methods for treating resistant tumors Methods for treating resistant tumors

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/38 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 333/56 (2006.01)

Patent

CA 2236543

This invention provides a series of substituted benzo[b]thiophenes useful in reversing multidrug resistance in a resistant neoplasm. The present invention also provides methods for reversing the multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituted benzothiophene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted benzothiophene in combination with an oncolytic agent.

L'invention concerne une série de benzo[b]thiophènes substitués utiles pour supprimer la résistance multiple aux anticancéreux d'un néoplasme résistant. L'invention concerne également des procédés pour supprimer la résistance multiple aux anticancéreux d'un néoplasme d'un mammifère, qui consistent à traiter celui-ci par un benzothiophène substitué. Elle concerne aussi des procédés pour traiter des néoplasmes chez un mammifère, consistant à administrer à celui-ci un benzothiphène substitué conjointement avec un agent oncolytique.

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