A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/38 (2006.01) A61K 31/216 (2006.01) A61K 31/34 (2006.01) A61K 31/343 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/445 (2006.01) A61K 31/4525 (2006.01) A61K 31/4535 (2006.01) A61K 31/55 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2202661
The present invention provides methods for reversing multidrug resistance in a resistant neoplasm by treating a mammal in need of said treatment with a substituded indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene. This invention also provides methods for treating neoplasms in a mammal which comprises administering to a mammal in need of this treatment a substituted indole, benzofuran, benzothiophene, naphthalene, or dihydronaphthalene in combination with an oncolytic agent.
La présente invention se rapporte à des procédés pour faire rétrocéder la résistance multiple aux anticancéreux dans un néoplasme réfractaire, en traitant un mammifère, dont l'état requiert un tel traitement, avec un indole, benzofurane, benzothiophène, naphtalène, ou dihydronaphtalène substitué. L'invention concerne également des procédés pour traiter des néoplasmes chez un mammifère, consistant à administrer à un mammifère, dont l'état requiert un tel traitement, un indole, benzofurane, benzothiophène, naphtalène, ou dihydronaphtalène substitué en association avec un agent oncolytique.
Chandrasekhar Srinivasan
Dantzig Anne Hollins
Shepard Robert Lee
Starling James Jacob II
Winter Mark Alan
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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